图书简介
This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer’s disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer’s disease. Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer’s agents Explains the role of phytomolecules and natural products in Alzheimer’s therapy Reviews preclinical ways to assess drugs focusing on Alzheimer’s disease Covers biomarker analysis for Alzheimer’s disease Discusses the onset and progression of Alzheimer’s disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.
Chapter 1: Alzheimer’s Disease: Epidemiology, Neuropathology, and Neurochemistry Raushan Kumar Chaudhary, Uday Venkat Mateti, Pukar Khanal, Kala Bahadur Rawal, Praneetha Jain, Vishal S Patil, Amit Kumar Shrivastava and B M Patil Chapter 2: Preclinical Approach: In vivo and In vitro Methods for Evaluation of Anti-Alzheimer’s Drugs Nilutpal Sharma Bora, Bhargab Jyoti Sahariah, Chanam Melody Devi and Banshongdor H. Mawlieh Chapter 3: Computational Insights into the Applications of Plant-Based Therapies in Alzheimer’s Disease Dibyajyoti Das, Satyendra Deka, Biswajit Devanath, Aparoop Das, Nongmaithem Randhoni Chanu and Ramen Kalita Chapter 4: Advances in Applying Computer-Aided Drug Design for Alzheimer’s Disease Biswajit Devanath, Satyendra Deka, Dibyajyoti Das, Hans Raj Bhat, Nongmaithem Randhoni Chanu and Kunal Bhattacharya Chapter 5: Biomarkers Analysis for Alzheimer’s Disease Shraddha M. Jadhav and Karan Kumar Chapter 6: Mechanistic Aspects of Neurodegeneration in Alzheimer’s Disease and the Role of Phytochemicals Trideep Saikia, Tutumoni Kalita, Bhanu P Sahu, Prakash Rajak, Bhargab Deka and Alakesh Bharali Chapter 7: Computational Modelling of BACE-1, AChE, and Phosphodiesterase Inhibitors as Anti-Alzheimer’s Agents Vishal S Patil, Jagadeesh Dodakallanavar, Pukar Khanal, B M Patil, Raushan K Chaudhary, Amit Kumar Shrivastava, Nongmaithem Randhoni Chanu, Darasaguppe R. Harish and Uday Venkat Mateti Chapter 8: Therapeutic Application of Natural Products in Alzheimer’s Disease Using Computational Methods Muhammad Aqib Shabbir, Muhammad Naveed, Maleeha Manzoor, Hafiz Muhammad Hurraira, Noor-ul-Ain and Fatima Zaidi Chapter 9: Analysis of Potential Alzheimer’s Disease Inhibitors Based on Computational Modelling with Multiple Targets Ankita Dubey, Vrishti M Thakur, Raja Chakraborty, G.N. Darwhekar, Rupesh Kushwah and Rakhi Khabiya Chapter 10: Virtual Screening: Pioneering the Future of Drug Discovery in Alzheimer’s Disease N. Yellasubbaiah, B. Sivakumar and B. Nagasudha Index
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