Biofilm Associated Antimicrobial Resistance and Its Recovery

生物膜相关抗菌素耐药性及其恢复

生物工程

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作      者
出  版 社
出版时间
2023年12月01日
装      帧
精装
ISBN
9781032250335
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页      码
264
开      本
254 x 178 mm (7 x 10)
语      种
英文
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图书简介
A biofilm is a collection of microbial cells that have adhered to biotic surfaces such as plant cuticles or animal epithelia, as well as abiotic surfaces such as rocky substratum or catheter exteriors. The life cycle of a microorganism includes the fundamental process of biofilm formation for survival in diverse and harsh environments since it is a protected mode of growth allowing colonisation of new habitats by dispersal of microbes from the microbial clusters. The biofilm bound microorganisms remain embedded in an extracellular polymeric matrix that protects the indwelling cells from surfactants, biocides, several invaders like protozoans, and defences offered by the hosts like phagocytic cells. The biofilm bound recalcitrant microbes induce chronic and nosocomial diseases, posing a serious threat to public health. It has been observed that various antimicrobial drugs are able to successfully remove the planktonic (freely suspended) states of microbes as compared to the sessile (substrate-bound) forms, thus resulting in the development of antimicrobial resistance.Modern pharmacological strategies targeting the biofilm matrix differ from the conventional methods of antibiotic usage. This includes the use of natural compounds such as plant bioactive molecules, antimicrobial peptides, green synthesised nanoparticles, or secondary metabolites from other organisms that not only prevent the rise of antimicrobial resistance but are also safe for the host tissues.Biofilm Associated Antimicrobial Resistance and Its Recovery provides a detailed and systematic review of alternative pharmacological developments in the field of biofilm research.Features:A narrative overview of the mechanism of biofilm formation and its role in the emergence of antimicrobial resistance.Recent research in the development of antibiofilm remedies involving biogenic compounds.Advancements
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