图书简介

1 Drugs and drug targets - an overview; Part A Drug targets - structure and function; 2 Protein structure and function; 3 Enzymes: structure and function; 4 Receptors: structure and function; 5 Receptors and signal transduction; 6 Nucleic acids: structure and function; Part B Pharmacodynamics and pharmacokinetics; 7 Enzymes as drug targets; 8 Receptors as drug targets; 9 Nucleic acids as drug targets; 10 Miscellaneous drug targets; 11 Pharmacokinetics and related topics; Case study 1: Statins; Part C Drug discovery, design, and development; 12 Drug discovery: finding a lead; 13 Drug design: optimizing target interactions; 14 Drug design: optimizing access to the target; 15 Getting the drug to market; Case study 2: The design of ACE inhibitors; Case study 3: Artemisinin and related antimalarial drugs; Case study 4: The design of oxamniquine; Part D Tools of the trade; 16 Combinatorial synthesis; 17 Computers in medicinal chemistry; 18 Quantitative structure-activity relationships (QSAR); Case study 5: De novo design of a thymidylate synthase inhibitor; Part E Selected topics in medicinal chemistry; 19 Antibacterial agents; 20 Antiviral agents; 21 Anticancer agents; 22 Cholinergics, anticholinergics, and anticholinesterases; 23 Drugs acting on the adrenergic nervous system; 24 Opioid analgesics; 25 Antiulcer agents; 26 Cardiovascular drugs; Case study 6: Steroidal anti-inflammatory agents; Case Study 7: Design of a novel antidepressant; Case Study 8: The design and development of aliskiren; Case Study 9: Factor Xa inhibitors; Case Study 10: Reversible inhibitors of HCV NS3-4A protease; Appendices

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