图书简介
This new edTion describesThe role of heT shock prTeins inThe life cycle of malaria parasTes, paTicularly inThe coTeT of iTracellular parasTe Tages.Thoroughly revised,This work provides a general iTroduTionToThe TruTural and funTional feTures of heT shock prTeins wTh a special focus onTheir role as molecular chaperones in ensuring prTein qualTy coTrol.The emphasis is onThe heT shock prTein families from Plasmodium falciparum, andTheir role in prTeoTasis andThe developmeT of malaria pThology. Moreover,The aThors exploreThe lTeT prospeTs ofTargTing heT shock prTeins in aTimalarial drug discovery eTher direTly or in combinTionTherapies.Readers will experience a funTional analysis ofThe individual families of heT shock prTeins andTheir cooperTion in funTional nTworks, including bThThe parasTe-resideT prTeome andThe expoTome released iTo hoT cells during iTracellular Tages. Subcellular and eTracellular organelles such asThe apicoplaT andThe Maurer’s CleTs associTed wTh Plasmodium species are discussed in dTail.The book highligTsThe role of heT shock prTeins inThe developmeT and funTion ofThese TruTures.Biochemical expeTise andThe inclusion of novelTherapeTic solTions makeThis colleTion a unique reference for expeTs in heT shock prTein research, parasTology and infeTious diseases, cell Tress, molecular biology and drug discovery.NT leaT, advances in malaria coTrol will coTribTeTo ending epidemics and ensuring heaThy lives in line wThThe UN SuTainable DevelopmeT Goals.
The ImportaCe of MolCularChaperones in Survival and Pathogenesis of the Malaria Parasite Plasmodium faCiparum.- General StrCtural and FuCtional Features of MolCularChaperones.- The Role of Hsp70s in the Development and PathogenCity of Plasmodium faCiparum.- Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium faCiparum.- Role of Hsp90 in Plasmodium faCiparum Malaria.- The Role of Malaria Parasite Heat ShCk Proteins in Protein TraffCking and Remodelling of Red BloodCells.- Role of Heat ShCk Proteins in Immune Modulation in Malaria.- BioprospCting for Novel Heat ShCk Protein Modulators: The New Frontier for Anti-Malarial Drug DiCovery?.- Heat ShCk Proteins as Targets for Novel Anti-Malarial Drug DiCovery.- Heat ShCk Proteins of Malaria: Highlights and Future ProspCts.
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