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able of Contents Section 1- Biology of Immune Cells Ch 1 B cells in aging, age-associated diseases and stem cell transplantation Daniela Frasca, Maria Romero Ch 2 T cell biology: changes with disease, aging, and hematopoietic stem cell transplantation Valquiria Bueno Ch 3 Plasma cells in autoimmunity Falk Hiepe, Tobias Alexander, and Andreas Radbruch Ch 4 CAR T cells for Autoimmunity Michael C. Milone Ch 5 Regulatory T cells for the treatment of autoimmune diseases Claudia Selck and Margarita Dominguez-Villar Ch 6 Mesenchymal Stromal Cells Derived Extracellular Vesicles Ines Colmegna and Janusz Rak Section 2 - Biology of Stem Cells Ch 7 Induced Pluripotent Stem Cells: the story of genetic reprogramming Richard K Burt Ch 8 Mesenchymal stromal cell biology and clinical application Severine Loisel & Karin Tarte Ch 9 Neural Stem Cell Biology Angela Genchi, Beatrice von Wunster, Paola Panina-Bordignon and Gianvito Martino Ch 10 Hematopoietic stem cells: Hierarchical versus Continuum Peter Quesenberry, Sicheng Wen, Laura Goldberg and Mark Dooner Ch 11 Biology of Umbilical Cord Blood Cells Gesine Kogler and Stefanie Liedtke Section 3 - Regulatory requirements Ch 12 Quality, Accreditation, and Regulation in HSCT and Cellular Therapy for Autoimmune Diseases Eoin McGrath, Joseph Schwartz, Phyllis I. Warkentin, Riccardo Saccardi, John A. Snowden Ch 13 EUROPEAN PERSPECTIVE ON CELLULAR THERAPY: GOOD TISSUE PRACTICE (GTP) VERSUS GOOD MANUFACTURING PRACTICE (GMP). Elodie Kerjean, Bechara Mfarrej, & Christian Chabannon Ch 14 GMP Facility Requirements in the United States of America Cheryl Stratton and Ann LeFever Section 4 - Mesenchymal Stem Cells for Immune Diseases Ch 15 Mesenchymal stromal cell therapy for acute graft versus host disease - from bench to clinical approval Erik Boberg and Katarina Le Blanc Ch 16 Adipose-Derived Stem Cells for Systemic Sclerosis Digital Ulcers Nicoletta Del Papa, Antonina Minniti, Francesca Pignataro, Wanda Maglione and Roberto F. Caporali Ch 17 Musculoskeletal stromal/progenitor cells-based cell therapy for Rheumatoid Arthritis (RA) Yves-Marie PERS, Dominique Farge and Christian Jorgensen Ch 18 Mesenchymal Stromal cells for Systemic Sclerosis Dominique Farge Ch 19 Mesenchymal stem cells (MSC) for systemic lupus erythematosus (SLE) Lingyun Sun and Xinran Yuan Ch 20 Mesenchymal stem/stromal cells for multiple sclerosis and other neurological diseases Antonio Uccelli, Tiziana Vigo and Alice Laroni Ch 21 Mesenchymal stromal cells for perianal fistulizing crohn’s disease Antonio Giordano and Julian Panes Ch 22 Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder Jessica M. Sun and Joanne Kurtzberg Section 5 - General concepts: HSCT for Autoimmune Diseases Ch 23 Animal models of bone marrow transplantation for autoimmune diseases Yasushi Adachi, Ming Li, Richard K. Burt, Naoki Hosaka, Susumu Ikehara Ch 24 Autologous HSCT conditioning regimens for autoimmune diseases Richard K Burt, Dominique Farge, Riccardo Saccardi, Kathleen Quigley, Xiaoqiang Han and John A. Snowden Ch 25 Immune reconstitution after hematopoietic stem cell transplantation in autoimmune disease Paolo A. Muraro and Maria T. Cencion Ch 26 Microbiota and immune response Ernst Holler, Hendrik Poeck, and Daniela Weber Ch 27 Infectious complications in patients undergoing HSCT for autoimmune diseases. Richard K Burt and Dominique Farge Ch 28 Early Toxicity and Supportive Care of HSCT for Autoimmune Diseases John A Snowden, Azza Ismail, Richard K Burt, Helen Jessop Ch 29 Late toxicity and supportive care of patients undergoing haematopoietic cell transplantation for autoimmune diseases Nina Salooja, Richard K Burt and John A. Snowden Ch 30 Transfusion Medicine Khaled El-Ghariani Ch 31 International Registries Sites / Indications / Activity for HSCT in Autoimmune Diseases: the European Society for Blood and Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR) John A. Snowden, Raffaella Greco, Manuela Badoglio, Myriam Labopin, Omar F. Davila Alvelo and Marcelo C. Pasquini Ch 32 Hematopoietic stem cell mobilization, collection, apheresis, and harvest procedures Emilian Snarski and Richard K Burt Section 6 - Allogeneic HSCT for Autoimmune disease Ch 33 Hematopoietic Stem Cell Donor Registries: Search Strategies and HLA Methodologies Catherine Stavropoulos-Giokas, Vasiliki Gkioka and Dominique Charron Ch 34 Allogeneic HSCT and Graft-versus-Host Disease (GvHD): general principles with reference to autoimmune diseases Jose Ros-Soto, Richard K Burt and John A. Snowden Ch 35 Haematopoietic cell transplantation in monogenic autoimmune diseases Su Han Lum, Emilie P Buddingh, Mary A Slatter and Arjan C Lankester Ch 36 Advances In The Pathogenesis And Treatment Of Immune Mediated Aplastic Anemia Shinji Nakao, Sabrina Giammarco and Andrea Bacigalupo Section 7- HSCT for autoimmune disease Multiple Sclerosis Ch 37 Magnetic Resonance Imaging in Multiple Sclerosis Flavia Nelson Ch 38 Multiple Sclerosis Azza Ismail, Richard K Burt, Joachim Burman, Basil Sharrack Ch 39 Disease-modifying therapies and supportive care of multiple sclerosis Edith Graham, Eileah Loda, and Roumen Balabano Ch 40 Autologous hematopoietic stem cell transplantation for Secondary Progressive Multiple Sclerosis Richard K Burt, Basil Sharrack, Roumen Balabanov, John Rose, Xiaoqiang Han, Kathleen Quigley and Riccardo Saccardi Ch 41 Autologous hematopoietic stem cell transplantation for Relapsing Remitting Multiple Sclerosis Richard K Burt, Basil Sharack, Joachim Burman, Flavia Nelson, John Rose, Xiaoqiang Han, Kathleen Quigley and Riccardo Saccardi Ch 42 Immune mechanisms of autologous hematopoietic stem cell transplantation for multiple sclerosis Joachim Burman Chronic Inflammatory Demyelinating Polyradiculoneuropathy Ch 43 Basics and interpretation of electrodiagnostic testing Hamza Malek Ch 44 Diagnosis and Differentiation of CIDP from other peripheral polyneuropathies Celine Labeyrie Fanny Urbain and Cristina Castilla Llorente Ch 45 Hematopoietic stem cell transplantation for chronic inflammatory demyelinating polyradiculoneuropathy Gavin Brittain, Richard K Burt, Basil Sharrack Neuromyelitis Optica Ch 46 Autologous and Allogeneic HSCT for AQP4-IgG positive Neuromyelitis Optica Spectrum Disorders Raffaella Greco, Shailee Shah, Sean J Pittock and Richard K Burt Systemic Sclerosis Ch 47 Systemic Sclerosis Katja Lakota, Katja Perdan Pirkmajer and John Varga Ch 48 The Systemic Sclerosis Heart Sanjiv J. Shah Ch 49 Scleroderma Renal Crisis with special considerations for Autologous Hematopoietic Stem Cell Transplant Marie Hudson, Harold L. Atkins and Cybele Ghossein Ch 50 Systemic Sclerosis and the Lung David G Kiely and Robin Condliffe Ch 51 AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN SYSTEMIC SCLEROSIS Dominique Farge, Zora Marjanovic, Richard K Burt Crohn Disease Ch 52 Crohn’s Disease: Incidence, Diagnosis, Standard Treatment, Prognosis, Outcome Measures Gabriel Marcellier MD, Xavier Treton Ch 53 Hematopoietic Stem cell transplantation an alternative to treat Crohn’s disease Milton Artur Ruiz, Montserrat Rovira, Elena Ricart, Roberto Luiz Kaiser Junior, Richard K Burt Type I Diabetes Mellitus Ch 54 Hematopoietic Stem Cell Transplantation for Type I Diabetes Mellitus Carlos Eduardo Couri and Maria Carolina Oliveira Systemic Lupus Erythematosus Ch 55 Hematopoietic stem cell transplantation for systemic lupus erythematosus (SLE) Tobias Alexander, Renate Arnold, Falk Hiepe, and Richard K Burt Celiac Disease Ch 56 Hematopoietic Stem Cell Transplantation for Refractory Celiac Disease type II Abdulbaqi Al-Toma Section 8 - Developing indications for HSCT Ch 57 Haematopoietic stem cell transplantation for Juvenile Idiopathic Arthritis Mario Abinun, Su Han Lum, Arina Lazareva, Paul Veys, Mary A Slatter Ch 58 Haematopoietic Stem Cell Transplantation for Rheumatoid Arthritis Ross Penglase, Robert D Sandler, John Moore and John A. Snowden Ch 59 Hematopoietic Stem Cell Transplantation for Behcet’s Syndrome Leandro Lara do Prado, Lilian Piron-Ruiz, Milton A. Ruiz, and Celio Roberto Goncalves Ch 60 Hematopoietic Stem Cell Transplantation and Myasthenia Gravis Osman Radhwi and Harold Atkins Ch 61 Autologous Haematopoietic Stem Cell Transplantation in Stiff Person Spectrum Disorder Zeid Yasiry, Richard K Burt, Basil Sharrack Ch 62 Hematopoietic Stem Cell Transplant-Based Treatment for Psychiatric Disorders Sophia Chaudry and Sander Markx Ch 63 Hematopoietic Stem Cell Transplantation for Psoriasis and Pemphigus Vulgaris Floyd Silva, John Durkin and Leslie Andritsos Section 9 - Ethics and economics Ch 64 Health Economics of Multiple Sclerosis Daniel M. Hartung Ch 65 Ethics of Stem Cells and Stem Cell Transplantation for Autoimmune diseases Kevin FitzGerald SJ Ch 66 Is Healthcare a Human Right? Lawrence J. Metzger Ch 67 Appendices Indira Arnautovic and Kathleen Quigley

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