图书简介
The difficulty in treating cancer may be due to its "complexity", in the mathematical physics sense of the word. Tumors evolve and spread in response to internal and external factors that involve feedback mechanisms and nonlinear behavior. The nonlinear interactions among cells, and between cells and their environment are crucial for developing a sufficiently detailed understanding of the system’s emergent phenomenology. In the case of cancer, controlling the system’s behavior will mean the ability to treat and cure the disease. Physicists have been studying various complex, nonlinear systems for many years using theoretical, mathematical, computational, and experimental approaches. These investigations have provided insights that allow physicists to make unique contributions towards the treatment of cancer.
This interdisciplinary book presents recent advancements in physicists’ research on cancer. A variety of physical, biochemical, mathematical, and computational techniques as well as experimental and clinical data are used to gain a deeper molecular and cellular understanding of the horrific disease that is cancer.
Uncertainty and Sensitivity Analyses Methods for Agent-Based Mathematical Models: An Introductory Review; Game Theory Cancer Models of Cancer Cell-Stromal Cell Dynamics Using Interacting Particle Systems; Occupancy and Fractal Dimension Analyses of the Spatial Distribution of Cytotoxic (CD8+) T Cells Infiltrating the Tumor Microenvironment in Triple Negative Breast Cancer; Cooperation among Tumor Cell Subpopulations Leads to Intratumor Heterogeneity; Cell Mechanics Drives Migration Modes; Physics of the Extracellular Matrix and Biology of Tumors — a Close Relationship; Computational Modeling and Experimental Investigations to Enhance the Successful Response of anti-PD-1 Cancer Immunotherapies; The Physical Microenvironment of Tumors: Characterization and Clinical Impact; The Architecture of Co-Culture Spheroids Regulates Tumor Invasion Within a 3D Extracellular Matrix; Investigations of Interactions between Altretamine and Model Membranes: Spectroscopic and Calorimetric Analysis; Kinetic Aspects of the Interplay of Cancer and the Immune System; Comparison of the Atavistic Model of Cancer to Somatic Mutation Theory: Phylostratigraphic Analyses Support the Atavistic Model
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