图书简介
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR Cas/9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore of these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition’s simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Preface; Basic Definitions and Principles: Introduction (Thierry VandenDriessche); Basic Definitions and General Principles (Daniel Scherman); History of Gene Therapy (Serge Braun); Genetic Pharmacology Using Synthetic Deoxyribonucleotides (Jean-Christophe Francois and Carine Giovannangeli); Principles of RNAi Trigger Expression for Gene Therapy (Lisa J Scherer and John J Rossi); On Demand Alternative Splicing for Gene Rescue (Stéphanie Lorain and Luis Garcia); Nuclease-Mediated Targeted Genetic Correction (Dieter C Gruenert, Hamid Emamekhoo and R Geoffrey Sargent); Genome; Vectors and Gene Delivery Techniques: γ-Retrovirus- and Lentivirus-Derived Vectors for Gene Transfer and Therapy (Caroline Duros and Odile Cohen-Haguenauer); Adenovirus Vectors (Stefan Kochanek); Adeno-Associated Virus (AAV) Vectors (Aurélie Ploquin, Hildegard Büning and Anna Salvetti); Herpes Simplex Virus (HSV-1)-Based Vectors: Applications for Gene Transfer, Gene Therapy, Cancer Virotherapy (Matias E Melendez, Aldo Pourchet, Anna Greco and Alberto L Epstein); Non-Viral DNA Vectors (Martin Schleef); Macromolecular Conjugates for Non-Viral Nucleic Acid Delivery (Mark Ericson, Kevin Rice and Guy Zuber); Auto-Associative Lipid-Based Systems for Non-Viral Nucleic Acid Delivery (Virginie Escriou, Nathalie Mignet and Andrew Miller); Hydrodynamic-Pressure-Based Non-Viral Nucleic Acid Delivery (Takeshi Suda, Kenya Kamimura, Guisheng Zhang and Dexi Liu); Electrotransfer/Electroporation for Non-Viral Nucleic Acid Delivery (Pascal Bigey, Richard Heller and Daniel Scherman); Imaging of Gene Delivery (Georges Vassaux, Peggy Richard-Fiardo, Béatrice Cambien and Philippe Franken); Therapeutic Applications: Oncolytic Adenoviruses for Cancer Gene Therapy (Gunnel Hallden, Yaohe Wang, Han-Hsi Wong and Nick R Lemoine); Progress in DNA Vaccine Approaches for Cancer Immune Therapy (Geoffrey D Hannigan and David B Weiner); Adoptive Immunotherapy and CAR-T Cells (Daniel Scherman); Gene Therapy of Severe Combined Immunodeficiencies (Salima Hacein-Bey-Abina); Gene Therapy of the Beta-Hemoglobinopathies (Emmanuel Payen, Charlotte Colomb, Olivier Negre, Marina Cavazzana Calvo, Salima Hacein-Bey Abina, Yves Beuzard and Philippe Leboulch); Gene Therapy for Hemophilia A and B (Nisha Nair, Marinee Chuah and Thierry Vanden Driessche); Experimental and Clinical Ocular Gene Therapy (Alexis-Pierre Bemelmans and José-Alain Sahel); Gene Therapy of Neurological Diseases (Lisa M Stanek, Lamya S Shihabuddin and Seng H Cheng); Genetic Therapy of Muscle Diseases: Duchenne Muscular Dystrophy (Takis Athanasopoulos, Susan Jarmin, Helen Foster, Keith Foster, Jagjeet Kang, Taeyoung Koo, Alberto Malerba, Linda Popplewell, Daniel Scherman and George Dickson); Gene Therapy of Cystic Fibrosis (Stephen Hart); Induced Pluripotent Stem Cells and Gene Targeting for Regenerative Medicine (Jizhong Zou and Linzhao Cheng); Gene Vector Production: Production and Purification of Viral Vectors and Safety Considerations Related to Their Use (Otto-Wilhelm Merten, Matthias Schweizer, Parminder Chahal and Amine Kamen); Production and Purification of Plasmid Vectors (Martin Schleef)
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