图书简介
This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of total Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. Each chapter contains a brief introduction to the topic, clinical utility of the analyte(s), and useful notes to help laboratorians easily reproduce the protocols discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, is a great resource for laboratorians who are already using mass spectrometry or thinking of introducing this technology to their laboratories.
Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology.-燪uantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).-燪uantitation of the Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Plasma Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS).-燬imultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS .-燪uantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).-燪uantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).-燪uantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS.-燪uantitation of Buprenorphine, Norbuprenorphine, Buprenorphine Glucuronide, Norbuprenorphine Glucuronide, and Naloxone in Urine by LC-MS/MS.-燗 Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantification of Plasma Busulfan.-燞igh-Throughput Quantitation of Busulfan in Plasma Using Ultra-Fast Solid Phase Extraction Tandem Mass Spectrometry (SPE-MS/MS).-燪uantification of 11-Carboxy-Delta-9-Tetrahydrocannbinol (THC-COOH) in Meconium Using Gas Chromatography Mass Spectrometry (GC/MS).-燪uantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).-燙etirizine Quantification by High Performance Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS).-燪uantification of Docetaxel in Serum Using Turbulent Flow Liquid Chromatography Electrospray Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS).-燙omprehensive Urine Drug Screen by Gas-Chromatography Mass Spectrometry (GC/MS).-燘road Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry.-燞igh Resolution Mass Spectrometry for Untargeted Drug Screening.-燪uantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine Using Liquid Chromatography-Tandem Mass Spectrometry(LC-MS/MS).-燪uantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem mass Soectrometry (TFLC-MS/MS).-燪uantification of Iohexol in Serum by High Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).-燪uantitation of Teriflunomide in Human Serum/Plasma Across a 40,000-Fold Concentration Range by LC/MS/MS.-燚etermination of Menthol in Plasma and Urine by Gas Chromatography-Mass Spectrometry (GC/MS).-燚evelopment of an Assay for Methotrexate and its Metabolites 7-Hydroxy Methotrexate and DAMPA in Serum by LC-MS/MS.-燪uantitative, Multidrug Pain Medication Testing by Liquid Chromatography ? Tandem Mass Spectrometry (LC-MSMS).-燪uantification of Free Phenytoin by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS).-燚etection of Stimulants and Narcotics by Liquid Chromatography Tandem Mass Spectrometry and Gas Chromatography Mass Spectrometry for Sports Doping Control.-燪uantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
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