Fast Facts: Comprehensive Genomic Profiling

医学生物化学

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出  版 社
出版时间
2020年01月01日
装      帧
ISBN
9783318068184
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页      码
108
语      种
英文
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图书简介
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. ’Fast Facts: Comprehensive Genomic Profiling’ provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject.Contents:• Genetic mutations and biomarkers• Understanding next-generation sequencing• Elements of comprehensive genomic profiles• Role in precision oncology• Predictive and prognostic biomarkers• Overcoming barriers to genotype-directed therapy
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