图书简介

Preface ix 1 TiO2 Nanoparticles: Properties and Applications 1 Ozioma U. Akakuru, Zubair M. Iqbal, and Aiguo Wu 1.1 Introduction 1 1.2 Properties of TiO2 Nanoparticles 2 1.2.1 Crystal Properties 2 1.2.2 Optical Properties 3 1.2.3 Electrochemical Properties 5 1.3 Synthesis of TiO2 Nanoparticles 6 1.3.1 The Hydrothermal Method 6 1.3.2 Sol-Gel Method 8 1.3.3 Solvothermal Method 10 1.3.4 Chemical and Physical Vapor Deposition Method 11 1.3.5 Thermal Decomposition Method 12 1.3.6 Oxidation Method 13 1.4 Applications of TiO2 Nanoparticles 14 1.4.1 Nanobiotechnology 14 1.4.2 Nanomedicine 17 1.4.3 Wastewater Treatment 21 1.4.4 Air Treatment 26 1.4.5 Energy Devices 29 1.4.6 Water Splitting for Hydrogen Production 30 1.4.7 Food and Cosmetics 34 1.4.8 Soil Remediation 35 1.4.9 Pesticides Removal 36 1.4.10 Paint and Paper Productions 40 1.5 Conclusion 41 Acknowledgments 42 References 42 2 Toxicity of TiO2 Nanoparticles 67 Gohar I. Dar, Madiha Saeed, and Aiguo Wu 2.1 Introduction 67 2.2 Modes of Exposure, Biodistribution, Clearance, and Fate of TiO2 NPs 70 2.2.1 Inhalation 70 2.2.2 Oral Route 71 2.2.3 Injection 72 2.2.4 Dermal Route 73 2.3 Cell Death Pathways Induced by TiO2 NPs 74 2.3.1 Apoptosis 74 2.3.2 Autophagy 76 2.3.3 Crosstalk Between Apoptosis and Autophagy 76 2.3.4 Necrosis 77 2.4 Toxicity of TiO2 77 2.4.1 Cellular Uptake 78 2.4.2 Oxidative Stress Effectuates by TiO2 78 2.4.3 Genotoxicity 79 2.4.4 Reproductive and Developmental Toxicity 81 2.4.5 Carcinogenicity 81 2.4.6 Immunotoxicity of TiO2 NPs 83 2.4.7 Neurotoxicity of TiO2 NPs 83 2.4.8 Acute Toxicity of TiO2 84 2.4.9 Sub-acute Toxicity of TiO2 86 2.4.10 Sub-chronic Toxicity of TiO2 NPs 87 2.5 Alternative Perspective 88 2.6 Conclusion 89 Acknowledgments 89 References 89 3 Antibacterial Applications of TiO2 Nanoparticles 105 Chen Xu, Jianjun Zheng, and Aiguo Wu 3.1 Introduction 105 3.2 Antibacterial Effect of TiO2 Nanoparticle 107 3.3 Ion-Doped TiO2 Nanoparticles and Their Antibacterial Effect 113 3.4 Antibacterial Agent-Doped TiO2 Nanoparticles and Their Antibacterial Effect 120 3.4.1 Ag-Doped TiO2 Nanoparticles 120 3.4.2 Zn-Doped TiO2 Nanoparticles 123 3.4.3 Cu-Doped TiO2 Nanoparticles 123 3.5 Antibacterial Applications of TiO2-Based Nanoparticles 124 3.5.1 Medical Application 124 3.5.2 Environmental Application 125 3.5.3 Food Safety Application 126 3.6 Conclusion and Outlook 126 Acknowledgments 126 References 127 4 Surface-Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate) 133 Jie Lin and Aiguo Wu 4.1 Introduction 133 4.2 SERS Effect of Nanomaterial Substrate 135 4.2.1 Mechanism of Non-metal SERS Platforms 135 4.2.2 Advantages for TiO2 SERS Substrate 136 4.2.3 SERS Mechanism of TiO2 SERS Substrate 137 4.2.4 Novel Methods to Improve TiO2 SERS Enhancement 139 4.3 TiO2 SERS Substrate Applied in Biosensing 144 4.3.1 Cell Capture on TiO2 Nanorod Arrays 144 4.3.2 Cell Capture Performance of TiO2 Coatings 147 4.4 Conclusions and Future Perspectives 150 Acknowledgments 151 References 151 5 Cancer Theranostics of White TiO2 Nanomaterials 153 Yang Gao, Sijia Sun, Zhibin Yin, Yanhong Liu, Aiguo Wu, and Leyong Zeng 5.1 Introduction 153 5.2 TiO2 as Inorganic Photosensitizer for Photodynamic Therapy 154 5.2.1 Photodynamic Therapy Principle 154 5.2.2 Ultraviolet Light Responsive Photodynamic Therapy 155 5.2.3 980 nm Near-Infrared Light Responsive Photodynamic Therapy 156 5.2.4 808 nm Near-Infrared Light Responsive Photodynamic Therapy 158 5.2.5 Organic/Inorganic Dual-Mode Photodynamic Therapy 161 5.3 TiO2 as Sonosensitizer for Sonodynamic Therapy 162 5.3.1 Sonodynamic Therapy Principle 162 5.3.2 Sonodynamic Therapy 162 5.3.3 High Intensity-Focused Ultrasound Therapy 166 5.4 TiO2 as Multifunctional Nanoprobes for Visualized Theranostics 167 5.4.1 Magnetic Resonance Imaging and Phototherapy 167 5.4.2 Fluorescent Imaging and Phototherapy 168 5.4.3 Multi-mode Imaging and Phototherapy 169 5.4.4 Drug Delivery and Synergistic Therapy 170 5.5 Conclusions and Future Perspectives 172 Acknowledgments 173 References 173 6 Cancer Theranostics of Black TiO2 Nanoparticles 185 Ting Dai, Wenzhi Ren, and Aiguo Wu 6.1 Introduction 185 6.1.1 Limitations of White TiO2 Nanoparticles in Cancer Treatment 185 6.1.2 Advantages of Black TiO2 Nanoparticles in Cancer Treatment 186 6.2 Preparations and Properties of Black TiO2 Nanomaterials 187 6.2.1 Hydrogenation Reduction Method 187 6.2.2 Hydrogen Plasma Method 187 6.2.3 Chemical Reduction Method 188 6.2.4 Properties of Black TiO2 Nanomaterials 188 6.3 Black TiO2 for Phototherapy 189 6.3.1 Black TiO2 for Photothermal Therapy 190 6.3.2 Black TiO2 for Photodynamic Therapy 194 6.3.3 Black TiO2 for Synergistic Photothermal and Photodynamic Therapy 194 6.4 Black TiO2 for Imaging-Guided Phototherapy 195 6.5 Black TiO2 for Synergistic Chemo-phototherapy 199 6.6 Black TiO2 x for Synergistic of Sonodynamic-Photothermal Therapy 202 6.7 Overview and Further Perspective 205 Acknowledgments 207 References 207 7 Neurodegenerative Disease Diagnostics and Therapy of TiO2-Based Nanoparticles 217 Xiang Gao, Jieling Qin, Zhenqi Jiang, Juan Li, and Aiguo Wu 7.1 Introduction 217 7.2 The Symptoms of Neurodegenerative Disease 219 7.3 Traditional Diagnosis and Treatment for NDs 220 7.3.1 Current Methods for the Diagnosis of NDs 220 7.3.2 Current Medicine for the Treatment of NDs 220 7.4 Nanoparticles in the Diagnosis and Treatment of NDs 221 7.4.1 The Diagnosis of ND Using NPs 221 7.4.2 The Treatment of ND Using NPs as Drug Delivery 222 7.5 The Diagnosis of NDs Using TiO2 222 7.6 The Therapy of NDs Using TiO2 225 7.6.1 The Therapy of NDs Using TiO2 as Drug Delivery Platform 225 7.6.2 The Therapy of NDs Using TiO2 as Light-Responsive Material 226 7.7 The Dilemma Situation of TiO2 in the NDs 226 7.8 Conclusion 228 Acknowledgments 228 References 228 Index 237

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