This book offers an overview of different experimental and computational approaches to study biological systems. The book starts with a chapter which presents different methods for integrative analysis of omics data. Subsequently, techniques are described which allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter approach is described on the basis of the model organism Escherichia coli as well as the human metabolism. Furthermore, the book deals with the application of such techniques to improve human health. For example, several chapters focus on recent progress in building genome-scale models of regulatory networks, which are used to evaluate causality in molecular processes. The book highlights the importance of such information for specific biological processes like the ageing of cells, the immune system and organogenesis. Finally, the book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with dynamic control of gene expression. Advanced Biotechnology Biotechnology is a broad, interdisciplinary field of science, combining biological sciences and relevant engineering disciplines, that is becoming increasingly important as it benefits the environment and society as a whole. Recent years have seen substantial advances in all areas of biotechnology, resulting in the emergence of brand new fields. To reflect this progress, Sang Yup Lee (KAIST, South Korea), Jens Nielsen (Chalmers University, Sweden), and Gregory Stephanopoulos (MIT, USA) have joined forces as the editors of a new Wiley-VCH book series. Advanced Biotechnology will cover all pertinent aspects of the field and each volume will be prepared by eminent scientists who are experts on the topic in question.

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