Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utlisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well-established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 4th Edition presents a comprehensive overview of this important area of research. Written in a lively style by one of the leaders in the field and presented in full colour, this fourth, expanded edition has been fully updated with the latest discoveries. Major additions include recent information on iron and the immune system, heme transport, both systemically and intracellular, and the new role of a number of divalent metal transporters. The book is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.

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