图书简介

Preface; Introduction; 1. Parameters for Pesticide QSAR and PBPK/PD Models To Inform Human Risk Assessments; M. R. Goldsmith, J. C. Johnson, D. T. Chang, R. Tornero-Velez, J. B. Knaak, and Curtis C. Dary; Chiral Isomers/Toxicity/Separation/Metabolism; 2. Chiral Chemistry and Toxicity Assessments for Pyrethroid Pesticides; Robert W. Gerlach; 3. Direct Chiral Separation of Pyrethroid Isomers by HPLC with Chiral Stationary Phases; Masahiko Okamoto; 4. Biotransformation and Enzymes Responsible for Metabolism of Pyrethroids in Mammals; Hideo Kaneko; Protein Binding, Gastrointestinal Absorption, Blood Brain Permeability, and Transport; 5. The Influence of Maturation on Rat and Human Physiological Processes Involving Protein and Lipoprotein Binding, Gastrointestinal Absorption, and Blood Brain Permeability and Transport of Pyrethroids; J. V. Bruckner, T. G. Osmitiz, S. Anand, D. Minnema, W. Schmitt, N. Assaf, and J. Zastre; Percutaneous Absorption; 6. 15 Factors of Percutaneous Penetration of Pesticides; Mai A. Ngo and Howard I. Maibach; 7. Mechanisms of Percutaneous Absorption of Pesticide Formulations; William G. Reifenrath; Liver/Tissue Metabolic Enzymes; 8. Human Metabolic Interactions of Pesticides: Inhibition, Induction, and Activation; Ernest Hodgson and Andrew D. Wallace; 9. Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics; Clement E. Furlong, Rebecca J. Richter, Lucio G. Costa, and Gail P. Jarvik; 10. Carboxylesterases: A Multifunctional Enzyme Involved in Pesticide and Lipid Metabolism; Matthew K. Ross and Mariola J. Edelmann; Neurotoxicity I; 11. Behavioral Changes in Adult and Young Rats as Indications of Cholinesterase Inhibition; Virginia C. Moser; 12. Comparison of Esterase Sensitivity, Metabolic Efficiency, and Toxicity Levels of Two Organophosphorus Insecticides: Parathion and Chlorpyrifos; Janice E. Chambers, Edward C. Meek, and Howard W. Chambers; 13. Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat; Charles Timchalk, Jordan Ned Smith, Andrea Hjerpe, Torka S. Poet, and Sookwang Lee; Neurotoxicity II; 14. Pyrethroid Actions on Sodium Channels: Isoform and Species Specificity; David M. Soderlund; 15. Extrapolating Dose in Vitro to Dose in Vivo of a Neurotoxic Pyrethroid Pesticide Using Empirical Approaches and a PBPK Model; Michael F. Hughes, Melissa P. L. Chan, James M. Starr, Timothy J. Shafer, Edward J. Scollon, and Michael J. DeVito; QSAR/Other Models; 16. In Silico Strategies for Modeling Stereoselective Metabolism of Pyrethroids; Daniel T. Chang, Michael-Rock Goldsmith, Rogelio Tornero-Velez, Yu-Mei Tan, Christopher M. Grulke, Ling-Jen Chen, Elin M. Ulrich, Andrew B. Lindstrom, Melissa A. Pasquinelli, James R. Rabinowitz, and Curtis C. Dary; 17. Quantitative Structure-Activity Relationships for Organophosphate Enzyme Inhibition; Christopher D. Ruark, C. Eric Hack, Peter J. Robinson, and Jeffery M. Gearhart; 18. Computational Approaches for Developing Informative Prior Distributions for Bayesian Calibration of PBPK Models; Jimena L. Davis, Rogelio Tornero-Velez, and R. Woodrow Setzer; PBPK/PD Models; 19. Use of Cytochrome P450-Specific Parameters and Human Biomarker Data To Develop a Human Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Dermal Chlorpyrifos Exposure; Corie A. Ellison, James B. Knaak, Robin McDougall, and James R. Olson; 20. Use of in Vitro Data in PBPK Models: An Example of in Vitro to in Vivo Extrapolation with Carbaryl; Miyoung Yoon, Gregory L. Kedderis, Yuching Yang, Bruce C. Allen, Grace Z. Yan, and Harvey J. Clewell; Editors’ Biographies; Indexes; Author Index; Subject Index

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