The potential for drugs to induce a range of cardiac adverse events is a critical issue facing the pharmaceutical industry; in the last 20 years, drug-induced QT prolongation and cardiac arrhythmias has represented an important cause of drug withdrawal. With FDA guidelines recommending stringent testing of new pharmaceuticals on the heart, the importance of cardiac electrophysiology is affecting an increasing number of professionals in a range of industries. This book will equip readers with a clear and solid foundation in the fundamentals of electrophysiology and pharmacology of the heart, explore clinical arrhythmia disorders and treatments, and relate this to the research and development of new medicines. Representing an integrative bench to bedside approach to understanding this critical drug safety phenomenon, this book begins with a comprehensive review of the mechanisms responsible for drug-induced arrhythmia, followed by an in-depth discussion of the current preclinical and clinical recording techniques. Additionally, a complete assessment of current methods to stratify cardiac risk in drug development is included. Most importantly, the book develops and outlines the novel strategies and key frameworks that increase the cardiac drug safety and drive down the risk of novel biopharmaceutical products in the future. Key Features • With the analysis of pertinent case studies relating to the cardiovascular toxicity of licensed and experimental medicines, the reader will be able to relate this knowledge to common problems facing the pharmaceutical and biotechnology industries today and be better equipped to tackle cardiac drug safety issues in research and industrial environments • Where other books in this field tend to be purely scientific, often requiring specialist knowledge of basic and clinical science, this book combines core scientific elements with a commercial and business approach to framing this key drug safety phenomenon • The authors, who are experts in this field, combine their strong academic and medical backgrounds with pharmaceutical industry commercial experience spanning multiple business functions and therapy areas

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